Groundbreaking Cancer Immunotherapy Grace Gawler interviews Dr Horst Lindhoffer Munich

On today’s edition of Navigating the Cancer Maze, Grace Gawler interviews Dr Horst Lindhoffer PhD about one of the most innovative and exciting cancer immunotherapy treatment breakthroughs in many years. Visit germancancertreatments.com for more information.

On Navigating the Cancer Maze – Cancer Immunotherapy – Ground-breaking treatment in Cancer Medicine Grace Gawler -August 2, 2013

 “Destroying cancer stem cells means fighting cancer at its roots”, says Horst Lindhofer, CEO of TRION Pharma. “Catumaxomab’s efficacy against this particularly aggressive and resistant population of cancer cells further supports its therapeutic potential for the treatment of EpCAM-positive carcinomas.”

On today’s edition of Navigating the Cancer Maze, I interview Dr Horst Lindhoffer PhD about one of the most innovative and exciting cancer treatment breakthroughs in many years. We know that The human immune system is usually quite effective at identifying and eliminating abnormal cells.

dr horst lindhofer
Dr Horst Lindhofer

 Cancer cells, however, can form tumors and spread throughout the body. Although chaotic in their behavior, cancer cells operate with high level intelligence to escape detection by our immune system’s control mechanisms. Often misunderstood, this is a fundamental principle in understanding how cancer cells behave and how immune recognition can be assisted. The new breakthrough cancer treatments capitalize on that information. It has been a long-standing vision of physicians and scientists to develop a treatment that can put the immune system back on track. TRION has achieved the goal with its trifunctional Triomab® antibodies. Listen to learn more or contact grace@germancancertreatments.com for further details.

Listen to this interview at:
http://www.voiceamerica.com/episode/72038/cancer-immunotherapy-ground-breaking-treatment-in-cancer-medicine
Catumaxomab (Removab®) is presently the only approved therapeutic antibody targeting EpCAM, a surface antigen that is widely expressed in the most frequent forms of human cancer. On April 20th this year, Removab® received EU approval for the intraperitoneal treatment of malignant ascites in patients with EpCAM-positive carcinomas. Removab® is the first product world-wide to receive a regulatory approval for this indication. With its trifunctional mode of action, Removab® represents a new generation of antibodies using the body’s own immune system to help fight the tumor cells.

For more information visit www.germancancertreatments.com Enquiries: To discover more about Horst Lindhoffer’s work with Trifunctional antibodies  – please email grace@germancancertreatments.com

EpCAM: EpCAM or epithelial cell adhesion molecule is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas, such as breast, lung, colorectal, gastric, prostate and ovarian cancer. Catumaxomab (Removab®) is the only approved anti-EpCAM antibody available.

Triomab®: Trifunctional antibodies : Triomab® antibodies bind to cancer-specific surface antigens and recruit both T cells as well as accessory cells, such as macrophages, dendritic cells and natural killer cells, to the tumor site. As a result, they provide for a new quality of cancer cell killing, activating both arms of the immune system – the adaptive one with cytotoxic T cells as effectors and the innate one including accessory effector cells.

dendritic cell image
dendritic cell image

Triomab® antibodies are therefore very effective in destroying cancer cells and show a therapeutic effect at very low doses. Triomab® antibodies are a development of TRION Pharma GmbH Catumaxomab was invented by TRION Pharma and has been developed with Fresenius Biotech.

Trifunctional Antibody Catumaxomab Triggers Vaccination Effect Against Cancer: On June 06, 2011 Munich, Germany TRION Pharma GmbH released and announced new information – the results from two different studies demonstrating catumaxomab’s capacity to activate the immune system in a way that can otherwise only be achieved through vaccination.  Continue reading “Groundbreaking Cancer Immunotherapy Grace Gawler interviews Dr Horst Lindhoffer Munich”

Out on a Limb – Desperate Times call for Desperate Measures Grace Gawler Appeals

The Eagles Syndrome Appeal: Gawler Family Member

It is a tragedy when a family member is ill  and requires treatment that cannot sourced locally and needs substantial funds to pay for it overseas. I see this situation often in my practice and understand the difficulties faced by  many of my patients; even more so since my own 21 surgical procedures – a personal journey I began in 1997.  In 2002 my survival necessitated seeking an overseas solution if I wanted a life. My illness (the result of a complication following routine surgery) devastated my already compromised finances and I found myself in my fifties relaunching my career and owning nothing!  Now that my son needs help; I cannot afford his surgery, so I decided that the most creative way of raising funds was through my ‘self-published’ book sales – a win-win for everyone. My son requires life-saving surgery in Los Angeles – delaying his treatment could severely compromise his life – the longer his medical situation is left unattended, the more challenging his surgery will be.    

To support  this cause – Please visit the Resources/Bookstore page at :
http://gracegawler.com/Institute/?page_id=1892
We are trying to raise $60,000 through book sales
Please send this blog link to friends in your address book….. Together – I sure we can make this happen!

Apologies to regular blog subscribers for my lack of correspondence during the past few months; a personal and imperative family issue has been occupying much of my time – hence the subject of this blog.  Trying to raise funds whilst respecting my son’s privacy has not been easy & we have tried many obvious avenues including many requests to his father – all without success. So – as time is ticking by for this beautiful young man  –  as the heading implies, desperate times call for desperate measures.

Some Background: D lives with me and has done so for 29 out of his 31 years –  he entered this world at Yarra Junction, Victoria on a stormy August night in 1980 into a life that held severe health challenges.  He remains my greatest teacher. Although D is no stranger to pain, watching his deterioration as he bravely manages the affects of Eagles Syndrome is a distressing daily event and so ironic, given my vocation is helping others.  I continue to support in every other way I can. Surgery has a high chance of success, but the longer the condition is left – the greater the risks. D needs some action soon.

As a child, Specialists said D would never be able to hear. As with Ian Gawler, whom I married when he had a 2 week prognosis; harnessing the same tenacity, I doggedly pursued healing options for D utilising the best of complementary and mainstream medicine. D can now hear without aid and he has achieved many amazing things. I am very proud of him.
Following my own recovery, I had been hoping to take a ‘breather’ from health related dramas – but it seems the universe has other ideas! About a year ago D began to be investigated for a stiff neck and jaw clicking.

Xray of Eagles Syndrome - note 2 long bony styloid processes (pointing towards spine)

The outcome – he was diagnosed with Eagles syndrome – a rare condition involving calcification, thickening and lengthening of the styloid process (a pointed piece of bone that extends down from the human skull, just below the ear.) See Xray left. As you can imagine these extended bones create havoc.

A normal styloid process length is approximately 2–3 cm and serves as an anchor point for several muscles associated with the tongue and larynx and other facial structures. Eagles Syndrome is diagnosed if the overall Styloid length in excess of 3 cm. In D’s case both styloid processes are grossly elongated … 6.5 cm and 5 cm! This excessive length has caused havoc with jaw and facial nerves and shoulder spasm; but not only is it painful, the growing styloid processes have already caused severe compression of both jugular veins. Continue reading “Out on a Limb – Desperate Times call for Desperate Measures Grace Gawler Appeals”

Grace Gawler Writes About Beliefs, Cancer & the Power of Placebo in Survival Part 3

Can placebo heal? Can placebo provide a short term burst of hope based on belief?  Remember from our first post that from Latin placebo means ‘I shall please’ whereas Nocebo means ‘I shall harm’. Just how powerful are words of power, thoughts and beliefs?
With these definitions in mind, consider the  following stories. They powerfully demonstrate how belief systems can either turn on or turn off the will to live and how inexplicable healing can sometimes occur through belief.  Consider the power of Sovereigns to heal in medieval  times and the power of prayer
It is interesting to remember how the Royal Touch was believed to heal and bless.  With the spread of Christianity, monarchs were seen as religious figures with magical or curative powers. It was believed that Royal Touch, the touch of the sovereign of England or France, could cure diseases due to the devine right of sovereigns. Members of the royal courts often propagandized that those receiving the Royal Touch were miraculously healed. André du Laurens, the senior physician of Henry IV, publicized findings that at least half of those that received the Royal Touch were cured within a few days. Then we have the story of St peregrinus – the Patron Saint of Cancer. 
Near the end of the thirteenth century a zealous young priest of the order of

Patron Saint of Cancer Patients

Servites fell ill with a painful cancer of the foot. He bore his trial without a murmur and, when it was decided that amputation should be performed, he spent the night preceding the operation in prayer before his crucifix. He then sank into a light slumber from which he awoke completely cured—to the amazement of the doctors who could no longer detect any trace of the disease. The holy man lived to the age of eighty and died in sanctity. He became known as St. Peregrinus, the patron saint of cancer.

In this context – I introduce  two other sources for placebo – Both are from an indigenous source. I encourage you to consider the difference between an uneducated person who accepts their cultural beliefs and background including those in authority and our  current Western style culture where education levels are  a higher standard and where tradition and authority is often scorned or rebelled against. Did these simple beliefs and rituals have a ‘magical’ placebo effect?

The following stories  from the 1800’s were both recorded by medical physiologist Walton Cannon and concern  Australian experiences – the first one being an indigenous Australian account and the second – a Kanaka from the Polynesian Islands. From his diary he states:
“Dr. S. M. Lambert of the Western Pacific Health Service of the Rockefeller Foundation wrote to me on several occasions as he had seen evidence of death from fear. In one case there was a startling recovery. At a mission at Mona Mona in North Queensland, were many native converts, but on the outskirts of the mission was a group of non-converts, including one “Nebo”, a famous witch doctor. The chief helper of the missionary was Rob, a native who had been converted. When Dr. Lambert arrived at the Mission he learned that Rob was in distress and that the missionary wanted him examined. Dr. Lambert made the examination, and found no fever, no complaint of pain, no symptoms or signs of disease. He was impressed, however, by the obvious indications that Rob was seriously ill and extremely weak. From the missionary he learned that Rob had had a bone pointed at him by Nebo and was convinced that, in consequence, he must die. Thereupon, Dr. Lambert and the missionary went for Nebo, threatened him sharply that his supply of food would be shut off if anything happened to Rob and that he and his people would be driven away from the  mission. At once Nebo agreed to go with them to see   Rob. He leaned over Rob’s bed and told the sick man that it was all a mistake, a mere joke…indeed, that he had not pointed a bone at all.
The relief, Dr. Lambert testifies, was almost instantaneous. That evening Rob was back at work, quite happy again and in full possession of his physical strength.
A less fortunate outcome is reported in the next account.

Continue reading “Grace Gawler Writes About Beliefs, Cancer & the Power of Placebo in Survival Part 3”

Grace Gawler Writes About Beliefs, Cancer & the Power of Placebo in Survival Part 3

Can placebo heal? Can placebo provide a short term burst of hope based on belief?  Remember from our first post that from Latin placebo means ‘I shall please’ whereas Nocebo means ‘I shall harm’. Just how powerful are words of power, thoughts and beliefs?
With these definitions in mind, consider the  following stories. They powerfully demonstrate how belief systems can either turn on or turn off the will to live and how inexplicable healing can sometimes occur through belief.  Consider the power of Sovereigns to heal in medieval  times and the power of prayer
It is interesting to remember how the Royal Touch was believed to heal and bless.  With the spread of Christianity, monarchs were seen as religious figures with magical or curative powers. It was believed that Royal Touch, the touch of the sovereign of England or France, could cure diseases due to the devine right of sovereigns. Members of the royal courts often propagandized that those receiving the Royal Touch were miraculously healed. André du Laurens, the senior physician of Henry IV, publicized findings that at least half of those that received the Royal Touch were cured within a few days. Then we have the story of St peregrinus – the Patron Saint of Cancer. 
Near the end of the thirteenth century a zealous young priest of the order of

Patron Saint of Cancer Patients

Servites fell ill with a painful cancer of the foot. He bore his trial without a murmur and, when it was decided that amputation should be performed, he spent the night preceding the operation in prayer before his crucifix. He then sank into a light slumber from which he awoke completely cured—to the amazement of the doctors who could no longer detect any trace of the disease. The holy man lived to the age of eighty and died in sanctity. He became known as St. Peregrinus, the patron saint of cancer.

In this context – I introduce  two other sources for placebo – Both are from an indigenous source. I encourage you to consider the difference between an uneducated person who accepts their cultural beliefs and background including those in authority and our  current Western style culture where education levels are  a higher standard and where tradition and authority is often scorned or rebelled against. Did these simple beliefs and rituals have a ‘magical’ placebo effect?

The following stories  from the 1800’s were both recorded by medical physiologist Walton Cannon and concern  Australian experiences – the first one being an indigenous Australian account and the second – a Kanaka from the Polynesian Islands. From his diary he states:
“Dr. S. M. Lambert of the Western Pacific Health Service of the Rockefeller Foundation wrote to me on several occasions as he had seen evidence of death from fear. In one case there was a startling recovery. At a mission at Mona Mona in North Queensland, were many native converts, but on the outskirts of the mission was a group of non-converts, including one “Nebo”, a famous witch doctor. The chief helper of the missionary was Rob, a native who had been converted. When Dr. Lambert arrived at the Mission he learned that Rob was in distress and that the missionary wanted him examined. Dr. Lambert made the examination, and found no fever, no complaint of pain, no symptoms or signs of disease. He was impressed, however, by the obvious indications that Rob was seriously ill and extremely weak. From the missionary he learned that Rob had had a bone pointed at him by Nebo and was convinced that, in consequence, he must die. Thereupon, Dr. Lambert and the missionary went for Nebo, threatened him sharply that his supply of food would be shut off if anything happened to Rob and that he and his people would be driven away from the  mission. At once Nebo agreed to go with them to see   Rob. He leaned over Rob’s bed and told the sick man that it was all a mistake, a mere joke…indeed, that he had not pointed a bone at all.
The relief, Dr. Lambert testifies, was almost instantaneous. That evening Rob was back at work, quite happy again and in full possession of his physical strength.
A less fortunate outcome is reported in the next account.

Continue reading “Grace Gawler Writes About Beliefs, Cancer & the Power of Placebo in Survival Part 3”