Cancer Vaccines | A survivors story|From Cancer Good Things Grow Grace Gawler

I encored a recent interview with Jeffery Deslandes on my Voice America Internet radio show today for the Christmas period for a special reason. Because his story is both true and inspirational.

I encored a recent interview with Jeffery Deslandes on my Voice America Internet radio show today for the Christmas period for a special reason. Because his story is both true and inspirational. As Jeffrey quotes in his recently released ;  book; “From Cancer Good Things Grow”;  there are about 4,000 new cases of NHL each year in Australia. 1600 Australian die from NHL each year. If this were our road toll and there was an effective way of preventing deaths of even half of that number – there would be campaigns and lots of public and political interest. Why is there such little  interest in cancer immunotherapies? Jeffrey Deslandes is just one of many who have had success with vaccine treatments.

The questions begs – Have we become so conditioned to believing that cancer is a one-way ticket and there’s nothing we can do apart from try alternative medicine and throw out the “conventional medicine” baby with the bathwater?  Have we been convinced that conventional cancer medicine doesn’t work and that all big Jeffrey Deslandes Book 001pharma wants you to do is stay sick to garnish the pockets of doctors?  Have we bought into the rumour that the war on cancer is lost?  These are common statements from the Google cancer entrepreneurs whose aim is to convince patients to follow them, buy their “one size fits all” cancer products and……… take no responsibility for patient outcomes.

I know of far too many  patients who are not here to be with their families this Christmas because they used “faceless” advice from books, CDs or the internet – leaving aside treatable and potentially curable treatments for their cancer until it became obvious that their attempts to replicate the “cures” they have read about; ultimately failed them. This year I have experienced a new phenomenon, receiving many emails from parents who have taken the natural cancer “healing” path with their children using bizarre nutritional regimens, GcMAF, Budwig and Gerson Diets to name a few – most read about these treatments on blogs. Some of these children have been 3 and 5 years of age.  I try my best to influence them towards excellent sources of conventional medicine – but after a few emails – I never hear from them again. This is truly exasperating!!

Genuine, well documented  stories of cancer treatment successes are much needed. Such is the story of how Melbournian Jeffery Deslandes recovered from Stage 4 recurrent lymphoma that had grown resistant to conventional treatment found his remission – now eight and a half years clear. Jeffery did not seek Alternative medicine treatments when his lymphoma recurred again and again; rather he looked outside the conventional box to see what else science-based medicine could offer.

By purchasing Jeffrey Deslandes book (soft Cover /eBook) – you can help to promote the immune therapy he had right here in Australia. All proceeds go toward making this treatment more available for those in our region. PLEASE spread the good news. Vaccine therapies as immunotherapies go wider than just lymphoma. Successes are appearing from many cancer types including melanoma, prostate cancer and many more. If these therapies can be investigated alongside immune cycle research; we may indeed have a two incredibly power non invasive cancer treatment allies. Scroll to end of blog to see the effect of melanoma vaccine.**

Excerpts from Jeffrey Deslandes book “From Cancer Good things Grow”.

 

Chapter 7 -The cancer Returns Again and Again

Non-Hodgkin’s lymphoma is a bit like buffalo grass; it is hard to get out all of the roots and it tends to grow back. I had been informed that my cancer was incurable. It was a real shock at the time.
Non-Hodgkin’s lymphoma (NHL) is Australia’s fifth most common cancer, yet has a very low profile, compared to more publicised cancers such as breast, ovarian, bowel, melanoma and leukaemia. There are about 4,000 new cases of NHL each year in Australia, with about 1,600 deaths each year. That’s about the same as the National Road Toll in this country. Each year we spend billions trying to stop idiots killing each other on the road, yet comparatively little on a disease which is poorly understood. While Australia’s economy is soon to be taxed with the introduction of a Carbon Tax to combat Climate Change. Funny that, I have never known anyone who has died from Climate Change, but I have known scores and scores of people who have succumbed to cancer. We need Governments to spend serious money on cancer research.

After my cancer had returned for the fourth time in 2006, the next mainstream cancer treatment outlined by my specialist, was an autologous stem cell transplant. An autologous stem cell transplant, refers to your own body’s stem cells being first harvested, you are then given high-dose chemotherapy to hopefully kill all cancer in your body, and your stem cells

Jeffrey Deslandes
Jeffrey Deslandes

are then re-infused to build up your white cells, which have been decimated by the chemotherapy. The other option was an allogeneic stem cell transplant; the same procedure but the stem cells are used from a matched donor who is obviously free from cancer. However, for this we would need to find a matched donor, since my brother Ron was not a match, and other brother David was no longer with us. I decided not to take the recommendation of my highly trained lymphoma specialist. I decided that I would need to take charge of my treatment, and find something with a different mode of attack. If something is not working, you don’t keep hitting it with the same old stick! Read on,,,,,,,,

Chapter 8 – Vaccine Therapy–The New Beginning

Through my association with Lymphoma Australia, a fine not-for-profit organisation dedicated to raising awareness and supporting lymphoma patients, I became aware of work being done on vaccines for cancer treatment. This work was still experimental or being proven in clinical trials, but it was not quackery, it was being carried out by highly qualified haematologists and scientists.

My diseased lymph node, and my immature dendritic cells, were processed in the laboratory to manufacture a dendritic cell idiotype vaccine to fight the cancer. It is termed idiotype, because the vaccine is grown from my own cancer cells, and is thus specifically tailored to the idiosyncrasies of my cancer. It is worth noting that there are over 30 sub-types of lymphoma alone, and it is my understanding that each and every lymphoma is going to be somewhat different in its individual characteristics. By using my own lymphoma, we got a perfect match, the exact antibody to my cancer. The laboratory grew the vaccine formulation to make 33 doses of vaccine, which were stored at minus 196 °C in liquid nitrogen, and could be kept for perpetuity. Each dose of vaccine is about 1 ml, about a fifth of a teaspoon, but it contains about five million cells. Yes, that’s five million cells, each with a message for my immune system. The message was “this is what the cancer looks like, now do your job like you are supposed to, and go seek and destroy”.  Excerpt: “From Cancer Good Things Grow”

Help save a life ……… Readers of this blog – please help us to help others through cancer education. By passing on this blog or an episode from Voice America – you could also help cancer patients to re-frame their cancer experience and learn about the nature of cancer and how to outsmart it with science-based medicine.

May your Christmas season be filled with joy, love, passion and compassion….

Until next time….

Grace

**Warning:  Below – graphic image melanoma – positive results from repeated vaccine cancer treatments.

Conclusions: Prolonged, repetitive VMCL vaccination immunotherapy appears to be a clinically effective means
of generating relatively high CR rates, useful clinical responses and long-term survivals, with little toxicity, but
remains notably under-explored. Successive immunomodulation might explain the results. Closer analysis of
repetitive dosing is required.

Melanoma vaccines
Successful application of repeated dosing with Melanoma vaccines. Research- Brendon Coventry

Cancer Doesn’t Stop for Christmas | Dealing with the Challenges-Grace Gawler Voice America

Navigating the Cancer Maze represents the culmination of my 40 years experience working at the coalface of cancer in what I call cancer supportive care medicine. As a young girl of about 8 years of age – I had two ambitions in life; to research cancer or become a veterinary surgeon. The universe works in mysterious ways. In 1976 I married a veterinarian who had cancer.

LISTEN TO GRACE GAWLER  VOICE AMERICA AUDIO
Click headphones to listen to today’s show at Voice America

Today’s Navigating the Cancer Maze, covers several areas important to Cancer patients.

In addition to this blog – gracegawlermedia – on Sunday 21st December 2014 – I will be launching a new blockbuster or should I say myth-buster blog – Grace Gawler Blog: The Thinking Person’s Guide to the Truth behind Common Cancer Mythology.

Navigating the Cancer Maze represents the culmination of my 40 years experience working at the coalface of cancer in what I call cancer supportive care medicine. As a young girl of about 8 years of age – I had two ambitions in life; to research cancer or become a veterinary surgeon. The universe works in mysterious ways. In 1976 I married a veterinarian who had cancer.

It happened just a few days before Christmas in 1974 – 40 years ago when I had just turned 21. Suddenly I became a carer of a cancer patient who was my boyfriend and employer.

My wedding day 28 Feb 1976 - 21 years and full-time carer
My wedding day 28 Feb 1976 – 21 years and full-time carer

 Like many today I had no experience in how to cope personally or how to help the patient who was my charge. I had to improvise and learn along the way. Added to this, my boyfriend, who later became my husband when he was given a prognosis 6 weeks to live; was an amputee. He had lost his leg to bone cancer just after Christmas, January 1975. He survived, we had 4 children and now 4 grandchildren. I learned a lot during that “hands-on period” that added to later qualifications. My story of those times is recorded in my Memoirs: Grace Grit and Gratitude. (2008 – eBook available)

See You tube: Grace Grit and Gratitude  Also visit on the menu of this blog –  “Ian Gawler Cancer?”

Moving forward to 2012 I realised that consulting with patients and public speaking was not enough. With cancer incidence rising, what I had learned needed a Global voice; an opportunity to take what I had learned so far and add medical expertise in current cancer treatments and research combined with patients’ experiences.

Available eBook - buy soft cover Australia only
Available eBook – buy soft cover Australia only

Patient’s need reliable and genuine information when they are in the fight for their lives! 2014 marks 2 years on air with Voice America’s Health and Wellness Channel hosting ‘Navigating the Cancer Maze’. We want as many people as possible to know about Navigating the Cancer Maze internet radio because my Charity The Grace Gawler Institute sponsors this show to provide education and information free to all in need. Please visit the Website for our Christmas Fundraiser to support the show for 2015: “Move the World with Grace”

On this week’s pre-Christmas show I discuss key issues for cancer patients that have been highlighted by our guests on Navigating the Cancer Maze throughout 2014; a year of challenges and excitements in the Global Cancer Community. We will take a look at the impact of some of cancer’s entrepreneurs Including Wellness Warrior-Jess Ainscough, who has influenced many patients to follow the natural path to cancer healing, albeit encouraged by the Ian Gawler recovery story, which as you know, was highly likely to have been a misdiagnosis.

Unfortunately, but as expected; Jess’s Epithelioid sarcoma, a cancer that moves slowly has now progressed to a serious degree. Her mum recently died from breast cancer doing the same regimen. Entrepreneurial patients like Jess Ainscough have a huge influence on cancer patient’s treatment decisions. I truly despair at these stories. I hear from cancer patients like Jess daily and see them in my practice with the most horrendous fungating cancers that one would would expect to see in a third world country. I am passionate to educate cancer patients about the dangers of taking the 100% natural therapies approach. As a trained naturopath and herbalist-I am horrified by what I see hear and read about natural cancer cures!
More on this visit-Science -based Medicine Blog and See  Jessica Ainscough Wellness Warrior

Finally….Cancer Doesn’t Stop at Christmas:While for some this is a happy time of year – for others Christmas and New Year celebrations can be very a difficult & emotional time for those currently dealing with life challenging illness, including patients’ families. Also challenging is the person who may be missing from this year’s Christmas table. Please see helpful resources below – also listen to today’s show for helpful tips
Many of my Guests on Navigating the Cancer Maze have authored some fine books. I have listed them below. These are books of substance that contain valid and useful information for patients and families. Recommended for Christmas gifts or personal reading

Resources/Books mentioned on today’s show from my 2014 Guests:
BOOKS

  1. From Cancer Good Things Grow Jeffrey Deslandes – 8.5 year survivor of stage 4 lymphoma after failed treatments – 4 recurrences. Success with Dendritic cell vaccines. Pub  Balboa Pressall proceeds go to R& D Of DC Vaccines.
  2. “Three Months: A Caregiving Journey from Heartbreak to Healing” by Dietrich Stroeh Buy at Amazon
  3.  Recent Release-” Survivorship: Living Well During and After Cancer” by Dr Barrie Cassileth –
    Buy at:  http://www.cancercarestore.com/survivorship-living-well-during-and-after-cancer
  4. “Bad to the Bone: the True Story of David Tuccaro, Jr” – by David Tuccaro, Jr successful leukemia treatment- Buy at Amazon
  5. “Lead With Your Heart: Creating a Life of Love, Compassion, and Purpose”  by Regina Cates Buy at Amazon
  6. “The Man who Saved a Million Lives” – by Prof Ian Frazer Buy at Amazon
  7. Spontaneous Remission: An Annotated Bibliography by Caryle Hirshberg and Brendon O’Regan – Access this via IONS- Free chapter downloads:
    http://noetic.org/library/publication-books/spontaneous-remission-annotated-bibliography/

Movies:

Debbie Franke Ogg had a Hollywood Movie made about her life and recovery from Stage 4 Lymphoma. It starred Sam Neil and Anne Archer. First titled “A Leap of Faith” – the movie was later titled a “Question of Faith”. Debby is perhaps one of the few of millions who had a spontaneous remission from her cancer without medical treatment. The movie can be found online by typing the title into Google. Now a therapist in NY USA – Watch Movie online   Contact Debby.

Cancer Doesn’t Stop at Christmas: Help for those who may have lost a loved one this year. Resources provided by Beth O’Brien: a guest on this year’s Navigating the Cancer Maze.
http://seasonsofgrief.com.au/about-beth/
www.australiancelebrations.com.au
http://deathcafe.com/
https://www.suicidecallbackservice.org.au
http://www.livingisforeveryone.com.au
http://suicidepreventionaust.org/resources/
BOOK recommended by Beth:
Dying to be Free: A healing guide for families after a suicide (Beverly Cobain, Jean Larch) buy at Amazon
The Grief Recovery Handbook: The action program for moving beyond Death, Divorce and other losses by John W James and Russell Friedman Buy at Amazon

Listen to today’s show at
http://www.voiceamerica.com/episode/82356/cancer-doesnt-stop-for-christmas-dealing-with-the-challenges

Join Voice America for free: http://www.voiceamerica.com/member/register

OR Join this blog for weekly updates delivered to your email box.

Until next time – Compliments of the Christmas Season

Grace

Options, Choices and Treatments for Cancer Recovery| Navigating the Cancer Maze

New cancer treatments are always controversial; BUT – this method is not a treatment. It’s a smart approach. A Smart approach that utilizes all that we know so far about cancer. It works because ultimately; our innate immune system knows what to do.

Options, Choices and Treatments for Cancer Recovery: De mystifying the oscillating the immune cycle.

When my ex husband and I had the idea for starting support groups for cancer patients in the early 1980’s. cancer organizations, patients and doctors were initially not supportive. In fact they were skeptical. They could not see any possible therapeutic benefit could come from people attending a support group.  How wrong they were! Move forward Body rhythms diagram40 years! Yes this December marks my beginning working with cancer patients 40 years ago in a time when there was no support in the health system and no support groups. Now, the benefit of patients attending structured supports and the well being benefit is indisputable.

There are still many new areas to explore, which leads me to discussing the immune cycle. It would seem that during 2014 on Navigating the Cancer Maze – we uncovered and delivered some significant “missing” pieces of the cancer treatment puzzle. It is my hope that as 2014 comes to an end – that 2015 will truly usher in a new paradigm in cancer treatments. The foundation has been laid, extensive research already done, the concept has been introduced worldwide – the  immune cycle measurement is here – NOW!
Now it is up to cancer patients to prove Martin Ashdown and Brendon Coventry right….or wrong. I liked it when Martin Ashdown said – “We believe this is so, a breakthrough – but we are open to being proven wrong!” As in the early days of my first charitable  foundation – it was people power – patient power that made a difference to the success of the Cancer Support Group Movement. Once told there would likely be a measured benefit from attending a support group – the press broadcast the news and the patients came on board en masse!

New cancer treatments are always controversial; BUT – this method is not a treatment. It’s a smart approach. A Smart approach that utilizes all that we know so far about cancer. It works because ultimately; our innate immune system knows what to do. It is just in temporary overwhelm. So doesn’t it make perfect sense that to find the best time to work in synch within the cycle of each person’s immune system to add the best chemotherapy or monoclonal antibody or other targeted treatment. Isn’t this the personalized approach we have been searching for? We all thought it would come in a pill – not an approach and that’s a paradigm shift that some in the world of science and medicine are struggling with.

measuring immune cycleKnowing how one’s immune cycle oscillates holds a clue, “the missing link” that can direct doctors to seek the best time to treat patients in their personal window of opportunity. Then within the parameters of what we know they will have the best chance of a good response or complete response to treatment. (CR)

When cancer cells challenge us – they are also smart. They are a part of us created by our internal systems. You could define cancer as an internal systems error!  These cancer cells cleverly recruit our intelligent mechanisms using them for their own growth and survival. It seems a bit crazy that something that wants to survive – kills its host. But – that’s life! To listen to the latest Voice America related to this blog visit:
http://www.voiceamerica.com/episode/82056/options-choices-and-treatments-for-cancer-recovery

So – I believe as do Ashdown and Coventry – that if there is enough of the immune response left in a patient – that the cycle can still be measured and timed so administer the right treatment at the right time. It is simple enough – the only real cost being a series of blood tests. Then finding a doctor who will look at the science and research and say yes – they administer treatment during the 12 hour window of opportunity. The Grace Gawler Institute is keen to let you know and experience the immune cycle for yourself. Please Read more below or join the immune cycle registry at:

http://www.gracegawlerinstitute.com/immune-cycle-registry/ also see our Next “Survivor Academy” Course!

Martin Ashdown and Brendon Coventry have built upon earlier excellent work in the study of chronobiology: Below are references given on Navigating the Cancer Maze today: I have provided abstract content as well as links.

Until next time……Grace

  • Annu Rev Pharmacol Toxicol. 2010;50:377-421. doi: 10.1146/annurev.pharmtox.48.113006.094626.
    Circadian timing in cancer treatments.
    Lévi F1, Okyar A, Dulong S, Innominato PF, Clairambault J.
    Author information
    Abstract
    The circadian timing system is composed of molecular clocks, which drive 24-h changes in xenobiotic metabolism and detoxification, cell cycle events, DNA repair, apoptosis, and angiogenesis. The cellular circadian clocks are coordinated by endogenous physiological rhythms, so that they tick in synchrony in the host tissues that can be damaged by anticancer agents. As a result, circadian timing can modify 2- to 10-fold the tolerability of anticancer medications in experimental models and in cancer patients. Improved efficacy is also seen when drugs are given near their respective times of best tolerability, due to (a) inherently poor circadian entrainment of tumors and (b) persistent circadian entrainment of healthy tissues. Conversely, host clocks are disrupted whenever anticancer drugs are administered at their most toxic time. On the other hand, circadian disruption accelerates experimental and clinical cancer processes. Gender, circadian physiology, clock genes, and cell cycle critically affect outcome on cancer chronotherapeutics. Mathematical and systems biology approaches currently develop and integrate theoretical, experimental, and technological tools in order to further optimize and personalize the circadian administration of cancer treatments.
    PMID:
    20055686
    [PubMed – indexed for MEDLINE]
  • http://www.ncbi.nlm.nih.gov/pubmed/20055686

Ann Pharm Fr. 2008 Jun;66(3):175-84. doi: 10.1016/j.pharma.2008.05.003.
[The circadian-timing system: a determinant of drug activity and a target of anticancer treatments].
[Article in French]
Lévi F.
Author information
Abstract
Cellular proliferation and drug detoxification are controlled over the 24h by the circadian-timing system, whose disruption can favor malignant processes. Thus, prolonged shift work appears to increase the risk of breast, colon or prostate cancer. Alterations in circadian physiology and/or molecular-clock genes accelerate cancer progression in experimental models and in cancer patients. In addition, anticancer treatments can also dampen or reinforce the circadian-timing system, as a function of dose and time of administration. The adjustment of anticancer-drug delivery to the circadian-timing system (chronotherapeutics) has allowed to reduce five-fold the incidence of severe adverse events as compared to constant rate infusion or wrongly-timed chronomodulated delivery in cancer patients. In experimental models, the best antitumor efficacy is usually obtained following treatment delivery near the least toxic time, a statement that also seems to apply to patients. Dedicated technologies include programmable in time pumps and rhythm monitors and are required for chronotherapeutics. Recent results have revealed that the optimal chronotherapeutic schedule could differ as a function of gender and circadian physiology. In conclusion, the circadian-timing system was shown to negatively control malignant proliferation via partly identified molecular mechanisms. The components of the circadian-timing system thus constitute new potential therapeutic targets in oncology. Mathematical models help toward a better understanding of the role of variability for the determination of the optimal chronotherapeutic schedule and constitute useful tools for the personalization of cancer chronotherapeutics.

http://www.ncbi.nlm.nih.gov/pubmed/18706346

Handb Exp Pharmacol. 2013;(217):261-88. doi: 10.1007/978-3-642-25950-0_11.
Cancer chronotherapeutics: experimental, theoretical, and clinical aspects.
Ortiz-Tudela E1, Mteyrek A, Ballesta A, Innominato PF, Lévi F.
Author information
Abstract
The circadian timing system controls cell cycle, apoptosis, drug bioactivation, and transport and detoxification mechanisms in healthy tissues. As a consequence, the tolerability of cancer chemotherapy varies up to several folds as a function of circadian timing of drug administration in experimental models. Best antitumor efficacy of single-agent or combination chemotherapy usually corresponds to the delivery of anticancer drugs near their respective times of best tolerability. Mathematical models reveal that such coincidence between chronotolerance and chronoefficacy is best explained by differences in the circadian and cell cycle dynamics of host and cancer cells, especially with regard circadian entrainment and cell cycle variability. In the clinic, a large improvement in tolerability was shown in international randomized trials where cancer patients received the same sinusoidal chronotherapy schedule over 24h as compared to constant-rate infusion or wrongly timed chronotherapy. However, sex, genetic background, and lifestyle were found to influence optimal chronotherapy scheduling. These findings support systems biology approaches to cancer chronotherapeutics. They involve the systematic experimental mapping and modeling of chronopharmacology pathways in synchronized cell cultures and their adjustment to mouse models of both sexes and distinct genetic background, as recently shown for irinotecan. Model-based personalized circadian drug delivery aims at jointly improving tolerability and efficacy of anticancer drugs based on the circadian timing system of individual patients, using dedicated circadian biomarker and drug delivery technologies.
http://www.ncbi.nlm.nih.gov/pubmed/23604483

Chronobiol Int. 2002 Jan;19(1):1-19.
From circadian rhythms to cancer chronotherapeutics.
Lévi F.
Author information
Abstract
Mammalian circadian rhythms result from a complex organization involving molecular clocks within nearly all “normal” cells and a dedicated neuroanatomical system, which coordinates the so-called “peripheral oscillators.” The core of the central clock system is constituted by the suprachiasmatic nuclei that are located on the floor of the hypothalamus. Our understanding of the mechanisms of circadian rhythm generation and coordination processes has grown rapidly over the past few years. In parallel, we have learnt how to use the predictable changes in cellular metabolism or proliferation along the 24h time scale in order to improve treatment outcome for a variety of diseases, including cancer. The chronotherapeutics of malignant diseases has emerged as a result of a consistent development ranging from experimental, clinical, and technological prerequisites to multicenter clinical trials of chronomodulated delivery schedules. Indeed large dosing-time dependencies characterize the tolerability of anticancer agents in mice or rats, a better efficacy usually results from treatment administration near the least toxic circadian time in rodent tumor models. Programmable in time multichannel pumps have allowed to test the chronotherapy concepts in cancer patients and to implement chronomodulated delivery schedules in current practice. Clinical phase I and II trials have established the feasibility, the safety, and the activity of the chronotherapy schedules, so that this treatment method has undergone further evaluation in international multicenter phase III trials. Overall, more than 2,000 patients with metastatic disease have been registered in chronotherapy trials. Improved tolerability and/or better antitumor activity have been demonstrated in randomized multicenter studies involving large patient cohorts. The relation between circadian rhythmicity and quality of life and even survival has also been a puzzling finding over the recent years. An essential step toward further developments of circadian-timed therapy has been the recent constitution of a Chronotherapy cooperative group within the European Organization for Research and Treatment of Cancer. This group now involves over 40 institutions in 12 countries. It is conducting currently six trials and preparing four new studies. The 19 contributions in this special issue reflect the current status and perspectives of the several components of cancer chronotherapeutics.
PMID:
11962669
[PubMed – indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/11962669
Cancer Causes Control. 2006 May;17(4):611-21.
Chronotherapeutics: the relevance of timing in cancer therapy.
Lévi F.
Author information
Abstract
BACKGROUND:
Cell physiology is regulated along the 24-h time scale by a circadian timing system composed of molecular clocks within each cell and a central coordination system in the brain. The mammalian molecular clock is made of interconnected molecular loops involving at least 12 circadian genes. The cellular clocks are coordinated by the suprachiasmatic nuclei, a hypothalamic pacemaker which also helps the organism adjust to environmental cycles. The rest-activity rhythm is a reliable marker of the circadian system function in both rodents and man. This circadian organization is responsible for predictable changes in the tolerability and efficacy of anticancer agents, and possibly also in tumor promotion or growth.
METHODS:
Expected least toxic times of chemotherapy were extrapolated from experimental models to human subjects with reference to the rest-activity cycle. The clinical relevance of the chronotherapy principle, i.e. treatment administration as a function of rhythms, has been demonstrated in randomized multicenter trials.
RESULTS:
Chronotherapeutic schedules have been used to safely document the activity of the association of oxaliplatin, 5-FU and leucovorin against metastatic colorectal cancer and to set up a new medicosurgical management of this disease which achieved unprecedented long term survival.
CONCLUSION:
The chronotherapy concept offers further promises for improving current cancer treatment options as well as for optimizing the development of new anticancer or supportive agents.
PMID:
16596317
[PubMed – indexed for MEDLINE]

Mol Med. 2012 Dec 6;18:1249-60. doi: 10.2119/molmed.2012.00077.
Circadian rhythm disruption in cancer biology.
Savvidis C1, Koutsilieris M.
Author information
Abstract
Circadian rhythms show universally a 24-h oscillation pattern in metabolic, physiological and behavioral functions of almost all species. This pattern is due to a fundamental adaptation to the rotation of Earth around its own axis. Molecular mechanisms of generation of circadian rhythms organize a biochemical network in suprachiasmatic nucleus and peripheral tissues, building cell autonomous clock pacemakers. Rhythmicity is observed in transcriptional expression of a wide range of clock-controlled genes that regulate a variety of normal cell functions, such as cell division and proliferation. Desynchrony of this rhythmicity seems to be implicated in several pathologic conditions, including tumorigenesis and progression of cancer. In 2007, the International Agency for Research on Cancer (IARC) categorized “shiftwork that involves circadian disruption [as] probably carcinogenic to humans” (Group 2A in the IARC classification system of carcinogenic potency of an agent) (Painting, Firefighting, and Shiftwork; IARC; 2007). This review discusses the potential relation between disruptions of normal circadian rhythms with genetic driving machinery of cancer. Elucidation of the role of clockwork disruption, such as exposure to light at night and sleep disruption, in cancer biology could be important in developing new targeted anticancer therapies, optimizing individualized chronotherapy and modifying lighting environment in workplaces or homes.
PMID:
22811066
[PubMed – indexed for MEDLINE]
PMCID:
PMC3521792
Free PMC Article

Chronobiol Int. 2012 Apr;29(3):227-51. doi: 10.3109/07420528.2012.658127.
Clock genes and clock-controlled genes in the regulation of metabolic rhythms.
Mazzoccoli G1, Pazienza V, Vinciguerra M.
Author information
Abstract
Daily rotation of the Earth on its axis and yearly revolution around the Sun impose to living organisms adaptation to nyctohemeral and seasonal periodicity. Terrestrial life forms have developed endogenous molecular circadian clocks to synchronize their behavioral, biological, and metabolic rhythms to environmental cues, with the aim to perform at their best over a 24-h span. The coordinated circadian regulation of sleep/wake, rest/activity, fasting/feeding, and catabolic/anabolic cycles is crucial for optimal health. Circadian rhythms in gene expression synchronize biochemical processes and metabolic fluxes with the external environment, allowing the organism to function effectively in response to predictable physiological challenges. In mammals, this daily timekeeping is driven by the biological clocks of the circadian timing system, composed of master molecular oscillators within the suprachiasmatic nuclei of the hypothalamus, pacing self-sustained and cell-autonomous molecular oscillators in peripheral tissues through neural and humoral signals. Nutritional status is sensed by nuclear receptors and coreceptors, transcriptional regulatory proteins, and protein kinases, which synchronize metabolic gene expression and epigenetic modification, as well as energy production and expenditure, with behavioral and light-dark alternance. Physiological rhythmicity characterizes these biological processes and body functions, and multiple rhythms coexist presenting different phases, which may determine different ways of coordination among the circadian patterns, at both the cellular and whole-body levels. A complete loss of rhythmicity or a change of phase may alter the physiological array of rhythms, with the onset of chronodisruption or internal desynchronization, leading to metabolic derangement and disease, i.e., chronopathology.
PMID:
22390237
[PubMed – indexed for MEDLINE]

Navigating the Cancer Maze Radio – USA Thanksgiving Holiday edition|Fran Drescher with Grace Gawler

The Cancer Schmancer Movement is changing the paradigm away from a cure toward cancer prevention and early detection. 90% of cancer is caused by environmental factors she says. By knowing what toxins to avoid we can reduce our cancer risk and by being proactive with annual screenings, people can be diagnosed earlier with a better chance to live longer & healthier.

Today on Navigating the Cancer Maze radio on Voice America – I have repeated our most popular interview since the show began in August 2012. It’s Thanksgiving weekend in the USA and Voice America staff are on holiday.  To locate my interview with Fran Drescher, if you haven’t heard it before – please select this link . Fran Drescher’s interview has encored several times on the show due to her popularity. Each week Navigating the Cancer Maze audience is growing. The show is being talked about by patient groups and audio files are being shared around the globe to those in need of valid and practical cancer information. I am not one for promoting celebrities – but I see something different in Fran Drescher, pro active and smart; based on her experience; she genuinely wants to make a difference in cancer. You will see what I mean when you take a look at her charity website www.CancerSchmancer.org 

GRACE GAWLER AND FRAN DRESCHER CANCER SCHMANCERThe Cancer Schmancer Movement is changing the paradigm away from a cure toward cancer prevention and early detection. 90% of cancer is caused by environmental factors she says. By knowing what toxins to avoid we can reduce our cancer risk and by being proactive with annual screenings, people can be diagnosed earlier with a better chance to live longer & healthier.

The impulse for Cancer Schmancer was born through Fran’s personal adversities. An added trauma for celebs is that their issues are played out on the public stage. Raped during a robbery in her home in 1985, she later was diagnosed with uterine cancer. A survivor, she has been an inspiration and an example to other women to not give up! Misdiagnosed by 8 doctors over a 2 year period – it was her dogged persistence to get a proper diagnosis that led to her surgery and recovery. The outcome could have been very different had she not been the type of person she is. But not all women persist with getting a diagnosis when they know something is not right with their health. Second, third, fourth opinions or more may be needed. Early diagnosis is a far easier path than dealing with advanced cancer and this is the path the Fran Drescher has taken in educating women about women’s cancers.

Fran divorced her first husband, writer and producer, Peter Marc Jacobson, who later came out as gay. Recent good news for Fran is that it seems found her real life Maxwell Sheffield when she married Dr Shiva Ayyadurai in September this year.

Fran is known for her innate ability to transform bad experiences into positives, writing a book titled Cancer Schmancer, where she wrote, “my whole life has been about changing negatives into positives.”

[youtube https://www.youtube.com/watch?v=GKMVz3qfn-I&w=560&h=315]

Footnote: About Thanksgiving: A Triumph of woman power and a listening president!

In 1789, following a proclamation issued by President George Washington, America celebrated its first Day of “Thanksgiving to God” under its new constitution. However it was a persistent woman, Mrs. Sarah Joseph Hale, the editor of Godey’s Lady’s Book who for thirty years, promoted the idea of a national Thanksgiving Day, contacting President after President until President Abraham Lincoln responded in 1863 by setting aside the last Thursday of November as a national Day of Thanksgiving. Over the next seventy-five years, Presidents followed Lincoln’s precedent, annually declaring a national Thanksgiving Day. Then, in 1941, Congress permanently established the fourth Thursday of each November as a national holiday.

http://www.cancerschmancer.org/frans-story

http://www.cancerschmancer.org/

http://www.gracegawlerinstitute.com/

[youtube https://www.youtube.com/watch?v=dU_Q8S8nvp0&w=560&h=315]

Happy Thanksgiving to all my USA listeners and supporters…

Until next time
Grace

Listen to Your Body Clock – Cancer and Your Health – Grace Gawler

We have knowledge of many cycles in our world. The tides, day and night are the most obvious. All creatures great and small are subject to these unseen forces that ultimately shape our life and our experience of it.” The circadian clock in mammals drives many physiological processes including the daily rhythms of sleep–wake behaviour, hormonal secretion, and metabolism. Less known, is that the clock also drives our immune cycles; an important factor in cancer treatment and recovery says Melbourne University Research Fellow Martin Ashdown, who has studied the phenomena for a long time. The science of taking advantage of the body’s own immune rhythm to improve efficacy of treatments is worth paying attention to whether its surgery, chemotherapy, immunotherapies, radiation/cyberknife; one thing is now clear – timing of treatment matters!

Research work of Synchronizing cancer treatment with the patient’s immune cycle has been recently launched into our awareness by Martin Ashdown and Brendon Coventry – and hopefully this blog, and my radio show Navigating the Cancer Maze on Voice America’s Health and Wellness Channel. Please spread the news!

With regards to timing – Did you know that majority of best-selling drugs in the United States target circadian gene products? Consider the case of statins, a class of drug that lowers cholesterol by inhibiting HMGCR (HMG-CoA reductase). HMGCR is the rate-limiting enzyme in cholesterol biosynthesis and its activity peaks during the night. Statins with short half lives showed maximal efficacy when taken in the evening (when their target gene was most active).This is just one example of chronotherapeutic practices positively impacting drug treatment. In other words – it’s all in the timing. (see resources below for more information on this).

In terms of Circadian rhythms and body clocks – simply reconsider an old message for good health. Early to bed and early to rise makes a man healthy, wealthy and wise!”

Take a look at the following diagram ( source Scientific American) to see what your body clock is doing – and at what time!

Circadian-rhythm-chart-on-physiologyBody clocks–-circadian rhythms—health; has been a hobby–horse of mine for some years. I am widely read on the subject and back more than 20 years ago – it became clear to me that there were tremendous health connections and implications for health and wellbeing and disease prevention – not only treating disease once it is evident.

So here is a Window of Opportunity for you
Readers of this blog – I invite you to stop for a moment and consider how your body clock affects your life. Is it possible to make some simple changes IN TERMS OF TIME & TIMING?

Do you listen to your body clock or constantly override it? Those of us who are disease free have the luxury of change and can enjoy the consequences-improved health. We don’t even have to have an immune cycle test – we SIMPLY NEED TO BECOME MORE AWARE of living in synch with ourselves and who and what is around us. It is the only real power that we have.

Being aware of your body clock and timing in your world, has one enormous benefit and this is also useful for anyone GG and Martin AShdown 31 Oct 14 interview  - Copy (2)dealing with a diagnosis of cancer – It brings you more into conscious connection with your body. Many patients over the past 40 years have told me that this is an unexpected gift that cancer brought to their lives. Some could view it as an opportunity for changing lifestyle, jobs etc…In terms of timing – the question begs what has happened in this person’s life that has perhaps interfered with their personal body clock? What could have caused a highly synchronized system to go into cellular chaos? These are big questions – but then again cancer is a big illness!
Left  Martin Ashdown and me – Grace Gawler.

Visit http://www.gracegawlerinstitute.com/immune-cycle-registry/ to join our exploratory pilot study -Measure your immune system.

A paper published by Department of Cellular and Structural Biology, UT Health Science CenterSan Antonio, Texas, USA; 2Department of Internal Medicine, Thuringia, Saalfeld, Germany; 3Department of Physiology, Jagiellonian University Medical College, Cracow, Poland states:

“There is a vast amount of literature suggesting that the photo-periodic environment (day/night) influences the incidence of cancer. While an association of chrono-disruption was initially proposed only for breast cancer, we recently suggested a more general theory, i.e., chrono-disruption may aggravate the development of many cancer types.”

Knowledge is power and knowledge of not only your body clock – but that of other mammals and nature. It’s all in the timing! Women’s’ menstrual cycle is perhaps the obvious one we know about. In nature – just watch a David Attenborough documentary to see the wonder of timing in nature!

We have knowledge of many cycles in our world. The tides, day and night are the most obvious. All creatures great and small are subject to these unseen forces that ultimately shape our life and our experience of it.” The circadian clock in mammals drives many physiological processes including the daily rhythms of sleep–wake behaviour, hormonal secretion, and metabolism.

Less known, is that the clock also drives our immune cycles; an important factor in cancer treatment and recovery says Melbourne University Research Fellow Martin Ashdown, who has studied the phenomena for a long time. The science of taking advantage of the body’s own immune rhythm to improve efficacy of treatments is worth paying attention to whether its surgery, chemotherapy, immunotherapies, radiation/cyberknife; one thing is now clear – timing of treatment matters! There is a window of opportunity within the 7 day cycle, Listen to Martin Ashdown to hear the story of how TIMING MATTERS!
Following on – some interesting articles and resources that relate to our body clock.

  • Complete clinical responses to cancer therapy caused by multiple divergent approaches a repeating theme lost in translation
    Coventry BJ1, Ashdown ML.1Discipline of Surgery, University of Adelaide, Royal Adelaide Hospital and Faculty of Medicine, University of Melbourne, Australia.
    SOURCE: http://www.ncbi.nlm.nih.gov/pubmed/22740774
  • Window of Opportunity – Martin Ashdown and Brendon Coventry:

          SOURCE:   http://www.immunaid.com.au/download/pressreviews_2014053001.pdf

  • The Clock Is Off: Bipolar Disorder and Circadian Rhythm – Scientific American – Apr 1, 2010 By Monica Heger
    Bipolar disorder may be linked to mutations affecting circadian rhythm
    |By Monica Heger
    “An off-kilter body clock can throw off our sleep-wake cycle, eating habits, body temperature and hormones—and mounting evidence suggests a malfunctioning clock may also underlie the mood cycles in bipolar disorder. In a new study led by psychiatrist Alexander Niculescu of Indiana University, researchers found that children with bipolar disorder were likely to have a mutated RORB gene, which codes for a protein crucial to circadian clock function.”
    Source: http://www.scientificamerican.com/article/the-clock-is-off/

Circadian gene expression atlas in mammals: Implications for biology and medicine
Ray Zhanga,1, Nicholas F. Lahensa,1, Heather I. Ballancea, Michael E. Hughesb,2, and John B. Hogenescha,2
Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; and bDepartment of Biology, University of Missouri, St. Louis, MO 63121

“We generated high-resolution multi-organ expression data showing that nearly half of all genes in the mouse genome oscillate with circadian rhythm somewhere in the body. Such widespread transcriptional oscillations have not been previously reported in mammals. Applying pathway analysis, we observed new clock-mediated spatiotemporal relationships. Moreover, we found a majority of best-selling drugs in the United States target circadian gene products. Many of these drugs have relatively short half-lives, and our data predict which may benefit from timed dosing.”

Source:  http://www.pnas.org/content/111/45/16219.abstract

For the more scientifically minded – don’t be put off by the title!

The Photoperiod, Circadian Regulation and Chronodisruption: The Requisite Interplay Between The Suprachiasmatic Nuclei and The Pineal And Gut Melatonin:

1Department of Cellular and Structural Biology, UT Health Science CenterSan Antonio, Texas, USA; 2Department of Internal Medicine, Thuringia, Saalfeld, Germany; 3Department of Physiology, Jagiellonian University Medical College, Cracow, Poland

“Part of their conclusion is that “Circadian rhythmicity is an integral component of normal and optimal physiology. Not only the SCN, but cells throughout the organism are equipped with internal clocks that control the molecular events that occur during each 24-hour period. These events appear to be precisely timed and in modern societies the intrinsic time keepers are provided with misinformation which, when prolonged, likely has ramifications in terms of increased pathologies.

It would seem judicious to take better care of the circadian network by providing appropriate photoperiodic cues, which currently seemed to be almost totally ignored. In addition, large amounts of this indoleamine (melatonin) is produced in the mucosa of GIT that seems to serve as local antioxidant and protective substance for the gut and liver against a variety of noxious agents, particularly the bacteria and their toxins, introduced into the gut with each meal.

There is a vast amount of literature suggesting that the photoperiodic environment influences the incidence of cancer. While an association of chronodisruption was initially proposed only for breast cancer, we recently suggested a more general theory, i.e., chronodisruption may aggravate the development of many cancer types.”
Source: http://www.ncbi.nlm.nih.gov/pubmed/21893686

Happy reading! Remember to visit our website: http://www.gracegawlerinstitute.com/immune-cycle-registry/

Until next time ………Grace

An Answer to Cancer – How Your Immune Body-Clock can assist Complete Remission | Navigating the Cancer Maze

Cancer affects everyone around the world in some way. Friends, relatives, children, mums and dads, grans and grandpas! It does not discriminate. It causes as much or perhaps even more misery than war because it reaches into every race, culture and country! If there was just one thing we could add to the recipe for Curing cancer or extending life with quality and well-being – wouldn’t we all be excited and interested?Do you want to know one important missing piece of the cancer puzzle? Two cancer researchers Martin Ashdown & Brendon Coventry have explored that question and yes they are excited!

How Your Immune Body-Clock can assist Complete Remission: (Please pass on the link to this blog to those in need)

Cancer affects everyone around the world in some way. Friends, relatives, children, mums and dads, grans and grandpas! It does not discriminate. It causes as much or perhaps even more misery than war because it reaches into every race, culture and country!  If there was just one thing we could add to the recipe for Curing cancer or extending life with quality and well-being – wouldn’t we all be excited and interested? Do you want to know one important missing piece of the cancer puzzle?  Listen to today’s show at: http://www.voiceamerica.com/episode/81479/an-answer-to-cancer-how-your-immune-body-clock-can-assist-complete-remission

Measuring immune cycles
Measuring immune cycles may be one missing piece of the cancer cure puzzle!

The show is free to air on the internet – live streaming listening at any time- free download – archived indefinitely.

Two cancer researchers Martin Ashdown & Brendon Coventry have explored that question and yes they are excited! So am I and so are some doctors and oncologists! Testing patients to map their immune cycle is not a complex exercise, but to do this, a system needs to be changed. All discoveries of worth seem to be hobbled for while – then accepted – struggling across the finish line…sometime after decades!

In 1983, Australian doctors J. Robin Warren and Barry Marshall isolated Helicobacter pylori, the bacterial cause of peptic ulcer disease. When the H. pylori hypothesis was developed, the doctors were certain that it would immediately gain universal acceptance and that within two years peptic ulcer therapy would be essentially an antimicrobial regimen”. This was far from the case. A 1986 book on Peptic Ulcer and its Drug Causation lends a page to the bacterial hypothesis, noting, “Whether these bacteria have an aetiological role in peptic ulcer gastritis is unknown”. At this time, doctors still prescribed drugs to reduce stomach acidity and monitored patients for complications. The story of Helicobacter pylori’s acceptance as a pathogenic agent reveals the issues with the acceptance of new thought even when there is validation and justification. http://www.jyi.org/issue/delayed-gratification-why-it-took-everybody-so-long-to-acknowledge-that-bacteria-cause-ulcers/

There are ethical laws in place; essential for the safety of humans in medicine. Changed laws of medical ethics, prevent a modern reprise of Pasteur’s heroic demonstration of his rabies vaccine through the vaccination of an infected boy. Measuring each cancer patients immune cycle and timing their treatment at the right time –  is nothing akin to that! It simply makes sense!

Perhaps one can understand the caution in prescribing an antibiotic. Measuring immune cycles and timing treatment for a better outcome? Now to my way of thinking this fulfills the old Hippocratic oath – “Above all, do no harm!”

The Grace Gawler Institute has a history of wanting to procure the best treatment options for cancer patients. We feel that by educating patients about their immune cycle and taking this material to their doctor – they can help change the face of cancer treatment in a risk free experiment to prove (or not) the research work of Martin Ashdown & Brendon Coventry.  This is why we have created the Cancer Immune Registry:

world cancer
Cancer affects everyone around the globe- it does not discriminate!

Background –  A cancer drug used for more than 20 years that is now providing oncologists with new information about how to best help patients achieve complete remission. The drug called interleukin-2, is providing cancer researchers with something akin to how the “Rosetta Stone” was used to unlock historical script; the outcome; mapping the immune cycle!

To understand how this is possible – join me with guest Martin Ashdown on Navigating the Cancer Maze on Voice America’s Health and Wellness channel ( internet radio)  to hear the full story of this amazing breakthrough.

Learn how you can access info about your immune cycle to assist cancer treatment efficacy.

RESOURCES:

1. http://www.voiceamerica.com/episode/81479/an-answer-to-cancer-how-your-immune-body-clock-can-assist-complete-remission

2. http://www.gracegawlerinstitute.com/immune-cycle-registry/

3. Martin Ashdown Window of Opportunity1 article: Australasian Science

4. MARTIN ASHDOWN A Matter of Time_AS_Article: article Australasian Science

5. VIDEO: Treatment of Metastatic Melanoma: Could Timing Be Everything? http://www.youtube.com/watch?v=yXX-9t8xiAo

6. CLICK  HERE FOR PRESS RELEASE VOICE AMERICA

7. CLICK HERE FOR VOICEAMERICA PRESS PASS RELEASE

An Answer to Cancer – How Your Immune Body-Clock can assist Complete Remission Grace Gawler with Martin Ashdown

Could timing of cancer treatments be the missing link in delivery of cancer therapies? Sounds too simple to be true? Two cancer researchers Martin Ashdown & Brendon Coventry are “immunological explorers” who not only unearthed a buried “treasure”; but they have also created a map for other innovative cancer “explorers” to follow. The “treasure” is a cancer drug used for more than 20 years that is now providing oncologists with new information about how to best help patients achieve complete remission. The drug called interleukin-2, is providing cancer researchers with something akin to how the “Rosetta Stone” was used to unlock historical script; the outcome; mapping the immune cycle!

An Answer to Cancer – How Your Immune Body-Clock can assist Complete Remission

Be sure to mark this coming weekend in your diary (7,8 November) to listen to this inspiring and significant edition of Navigating the Cancer Maze.

The Cancer Immune Cycle - A Window of Opportunity in Treatment Efficacy
The Cancer Immune Cycle – A Window of Opportunity in Treatment Efficacy

The show can be downloaded on itunes or reached at any time live streaming at the link below.
http://www.voiceamerica.com/episode/81479/an-answer-to-cancer-how-your-immune-body-clock-can-assist-complete-remission

The show is broadcast by Voice America on internet radio – but is distributed world wide and is a must for all cancer patients. Please select link at bottom of page to be directed to the eCard for this weeks edition. You can also sign up with Voice America to receive notice of ongoing shows. You can also sign up and follow this blog ( in the right side bar)  to receive weekly invaluable cancer information and Navigating the Cancer Maze links direct to your email inbox.

We know you will be inspired and encouraged by this show – so we have a call to action page on our website where cancer patients can be involved.

To join or read about the Cancer Immune Cycle Registry
please visit: http://www.gracegawlerinstitute.com/immune-cycle-registry/

 

This week……..An Answer to Cancer – How Your Immune Body-Clock can assist Complete Remission

Could timing of cancer treatments be the missing link in delivery of cancer therapies? Sounds too simple to be true? Two cancer researchers Martin Ashdown & Brendon Coventry are “immunological explorers” who not only unearthed a buried “treasure”; but they have also created a map for other innovative cancer “explorers” to follow. The “treasure” is a cancer drug used for more than 20 years that is now providing oncologists with new information about how to best help patients achieve complete remission. The drug called interleukin-2, is providing cancer researchers with something akin to how the “Rosetta Stone” was used to unlock historical script; the outcome; mapping the immune cycle! Join me with guest Martin Ashdown on Navigating the Cancer Maze to hear the story of this amazing breakthrough. Learn how you can access info about your immune cycle to assist cancer treatment efficacy.            Please Remember to like us on Facebook!

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Grace Gawler|What you Need to Know to Safely Navigate the Complementary Medicine Maze

With 30 years experience as a botanical medicine practitioner, I know that complementary medicines are very popular with cancer patients. Some believe they are an alternative to conventional medicine, rather than a complement or adjunct to other treatments. Patients tend not disclose natural medicines they are taking when seeing their oncologist. Some oncologists don’t ask. Some patients take an each way bet and use both conventional and “natural medicines”, but in most cases; they will likely never tell their doctor what they are doing.

Grace Gawler | What you Need to Know to Safely Navigate the Complementary Medicine Maze – October 31, 2014

LISTEN TO TODAY"S VOICE AMERICA AUDIO - GRACE GAWLER
CLICK HERE FOR TODAY”S VOICE AMERICA AUDIO – GRACE GAWLER

Today’s Navigating the cancer Maze will give insights With 30 years experience as a botanical medicine practitioner, I know that complementary medicines are very popular with cancer patients. Some believe they are an alternative to conventional medicine, rather than a complement or adjunct to other treatments. Patients tend not disclose natural medicines they are taking when seeing their oncologist. Some oncologists don’t ask. Some patients take an each way bet and use both conventional and “natural medicines”, but in most cases; they will likely never tell their doctor what they are doing. Why? Because they expect a prejudiced attitude, either ridiculing their choice or telling them to stop everything else they are taking or doing that is not considered real medicine. Herein lies an enormous modern-day dilemma because many alternative & complementary medicines are indeed REAL medicines with active phyto-chemical contents.In today’s episode and on this blog – I also share useful information about Curcumin as a adjunct medicine for cancer patients.

 

First of all Vitamin C

I often see patients in my practice who refuse to have pharmaceutical drugs….they are often shocked when I explain to them that so called “natural medicines” they are using may not be natural at all – These substances actually become a drug or pharmaceutical product once they are administered by intravenous injection or intramuscular. It doesn’t mean they wont work – but the fact is they are NOT natural as is often marketed. They may have natural origins or have active principles of natural origin that has been synthesized in the laboratory.
Perhaps the best example here is vitamin C – there is no way we could use ascorbic acid as an i/v infusion….It must be modified in the laboratory.

  • Now this may come as a shock to those to love all things natural…..but Unfortunately, nearly all the dietary supplements marketed as vitamin C these days are synthetic isolates, made with genetically modified (GMO) corn from factories in China. Ascorbic acid is theoranges-and-lemons product most often paraded as “vitamin C,” but it’s really only a laboratory-produced synthetic “isolate”—meaning it is a single component of vitamin C. Mother Nature knew what she was doing when she created vitamin C-rich fruits, berries and plants. Scientists now know that vitamin C isolates such as ascorbic acid do not provide the health benefits that whole food forms of vitamin C do.

    This subject is so important that I will be inviting an expert on to the show soon to discuss the topic…. so sign up to receive an ecard notification for details of when this show will go to air.Join this blog to be updated and informed about complementary medicines and cancer – select Follow or join in the form in the widget bar on the right. The blog will be delivered weekly to your email address.

  • Curcumin – Tumeric

Multiple Molecular Targets of Curcumin
Curcumin attacks multiple targets, providing the scientific basis for its effectiveness in many different diseases. Extensive research shows most diseases are caused by dysregulation of multiple signaling pathways–casting doubt on the effectiveness of monotherapy, which is limited to a single target.
Studies show curcumin modulates numerous molecular targets, including: regulating several cytokines and fibroblast growth factor-2 (gene expression), growth-factor receptors including modulation of androgen receptors (protein kinases), transcription factors, pro-inflammatory enzymes (including supression of COX-2, 5-LOX and iNOS and regulation of NF-κB), modulation of cell-cycle-related gene expression, blocking the adhesion molecules, downregulating anti-apoptic proteins and inhibiting multi-drug resistance.

curcumin.2jpgCurcumin is the most important active ingredient in turmeric, and makes up about 2-6% of the spice.

While therapeutic properties of turmeric have been known for centuries, modern science has identified the curcuminoids (phenolic compounds found in turmeric) and provides a scientific basis for many clinical uses of standardized curcumin.

Since turmeric contains very small concentrations of curcumin, look for standardized 95% curcumin (curcuminoids). Why? Hundreds of scientific and technical papers confirm: clinical results were obtained using curcumin (curcuminoids).Most Curcumin Products Contain 3 Curcuminoids
Commercial curcumin typically contains curcumin I (~77%), curcumin II (~17%) and curcumin III (~3%) as its major components.
For convenience, all curcuminoids are often referred to simply as “curcumin” even though turmeric contains a variety of different curcuminoids. Unfortunately, pure curcumin (including all known curcuminoids) is very poorly absorbed into your bloodstream after oral ingestion due to rapid metabolism in the liver and intestinal wall, and rapid systemic elimination.

Many curcumin products add piperine to improve absorption of curcumin. But piperine is a problem for many consumers because the additive should be taken cautiously (if at all) by anyone taking medications. According to the American Society for Pharmacology and Experimental curcuminTherapeutics, piperine is a potent inhibitor of drug metabolism, which means piperine spikes blood levels of many prescription medications.
A review of published research articles reveals piperine is toxic in experimental animals. Some research suggests piperine is safe in small amounts but large amounts of piperine could be damaging to the liver or other organs. Experts advise against consuming more than 15 mg of piperine per day. Piperine has known central nervous system (CNS) depressant effects. Finally, since piperine is a component of black pepper, consumers with a known allergy or hypersensitivity to black pepper should avoid piperine.

Check out BIOMOR Cucumin       READ MORE at: http://curcumin-turmeric.net

 

ALSO HIGHLY RECOMMENDED: SEE DR LUDWIG JACOB’S: Curcumin K2

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Available from Dr. Jacob’s Medical GmbH

Platter Str. 92

65232 Taunusstein

GERMANY            E-Mail: info@drjacobsmedical.de

Cheap versions of complementary medicines manufactured in countries with poor manufacturing and quality control standards are best avoided…….contamination is a big issue as well as growing, harvesting and all that happens to a the material before it gets to production. A recent example in May 2013 was the outbreak of symptomatic hepatitis A virus infections across 10 US states associated with pomegranate arils imported from Turkey and manufactured in the USA by an organic group. The source was traced to imported frozen pomegranate arils. These were identified as the vehicle early in the investigation by combining epidemiology—with data from several sources—genetic analysis of patient samples, and product tracing. There were 165 cases known to have been affected.Hepatitis A is spread when human feces contaminate food or when an infected food handler prepares food without using proper hygiene. Human feces are expected as the cause of the outbreak, according to the Wall Street Journal.

Remember – it’s best to ask for professional help when selecting products from the internet: Not only is it important to know the source of raw material – but the technique used in the manufacturing process and efficacy of the end product. Sometimes the pseudo-science that surrounds a product can be misleading.
Medicines and supplements purchased on the Interne need to be carefully scrutinized, especially if you are have cancer. Countries that have raw materials processed and manufactured with inadequate standards and poor quality control can be an issue.

Listen to today’s episode:Select the URL:

http://www.voiceamerica.com/episode/81372/what-you-need-to-know-to-safely-navigate-the-complementrary-medicine-maze

TO BE CONTINUED:

Why you Need an Experienced Guide to Help you Navigate the Cancer Maze.

Best Advice for anyone dealing with Cancer – Don’t try to Navigate the Cancer Maze alone! Find an experienced guide – someone you can trust and who is professional. If you have cancer or know someone who is dealing with cancer – please forward this blog link or the direct link to Voice America – where the Grace Gawler Institute’s internet radio show is hosted. We have a global audience. Listen live streaming or download episodes for free and listen later. Please help us in our mission to distribute reliable, valid and evidence-based cancer information – The lives of cancer patients depend upon truth in all branches and modalities of medicine.

Best Advice for anyone dealing with Cancer – Don’t try to Navigate the Cancer Maze alone! Find an experienced guide – someone you can trust and who is professional. If you have cancer or know someone who is dealing with cancer –  please forward this blog link or the direct link to Voice America – where the Grace Gawler Institute’s internet radio show is hosted. We have a global audience. Listen live streaming or download  episodes for free and listen later. Please help us in our mission to distribute reliable, valid and evidence-based cancer information – The lives of cancer patients depend upon truth in all branches and modalities of medicine.

A Helping Hand Grace GawlerAn experienced cancer guide who can navigate with a best of both worlds approach is becoming more and more essential in the escalating world of cancer information overload. While clearly patients want to be in charge & empowered when it comes to choosing cancer treatments, much of the knowledge being filtered to them is misleading; some just downright untruthful.

But on the other hand many patients have lost trust in the medical profession’s approach and treatment of cancer. Accordingly, this patient dissatisfaction has created a void in the system which has been readily filled by pseudo-science & magic promises of “cures” that don’t deliver. Time is precious for all patients but for some, a wrong path taken while navigating the maze, can have devastating consequences.

On today’s Navigating the Cancer Maze –  I share with you some of the relevant history of cancer that has led to today’s experience of cancer and how for thousands of years – Cancer has been deemed to be incurable. How can patients be discerning & use a best of both worlds approach?  In this episode you will learn about survival strategies & how patients can learn to embrace an intelligent and reliable approach. It is always useful to know about history and the history of medicine and cancer is no exception. By taking an historical walk through the centuries of cancer and medicine today to current time – you will learn why the cancer-cure is the most sought after prize on the planet. As a follow on oday’s episode is packed with useful – lifesaving information and strategies to help anyone effectively navigate the cancer maze.

Cancer is not a new disease of modern civilisation as many people think. Growths suggestive of osteosarcoma, a bone cancer; have been seen in Egyptian mummies.

The oldest complete example in the world of a human with metastatic cancer in a 3,000 year-old skeleton - Egypt
The oldest complete example in the world of a human with metastatic cancer in a 3,000 year-old skeleton – Egypt

Some of the earliest evidence of cancer is found among fossilized bone tumours, ancient Egyptian human mummies in, and ancient manuscripts. The oldest description of cancer was discovered in Egypt and dates back to about 3000 BC. Writings about the disease recorded on papyrus at the time, translated as, “There is no treatment.”

The ‘incurable’ nature of cancer and belief systems about cancer held by humanity for thousands of years is likely the reason that throughout the centuries, so many have wanted their claim to fame by trying to cure the so called incurable. Doctors even practised some strange and weird practises such as tying a live toad to a women’s breast to cure cancer.

Many of these were not scientists; some may have been genuine – for example, herbalists who stumbled across plants with anti cancer properties that may have played a part in a person’s recovery and this became folklore medicine – some of it is still of value today. However – this concept of cancer, has I believe – always left the door open for the charlatans and those who want to take advantage of an unsuspecting cancer public.

Over centuries – the trickster, charlatan, quack or snake oil salesman has been ready to peddle their products; whilst in modern times; information gathering pseudo-scientists, men in cowboy hats, banana-fuelled runners and aging entrepreneurs along with people who look barely old enough to vote, have jumped on the “I can cure cancer bandwagon” – follow me!  Some of them may mean well – but without an understanding of cancer they have become the dangerous persuaders of modern times.

But hey let’s not forget that modern medicine and science have delivered the best results so far in history. Chemotherapy was first developed at the beginning of the 20th century, although it was not originally intended as a cancer treatment. During World War II, it was discovered that people exposed to nitrogen mustard developed significantly reduced white blood cell counts. From thereon investigations into cancer cures were driven by yes, some big pharma profiteers – but also by genuine researchers and scientists. It has not been the best we could have done in terms of making people sick in order to help them get better- that seems to go against the grain of healing principles. Yet although it has been a rough road for some  – but many of my past patients would not be alive with out it! Immunotherapy has arrived on the scene….but there is more on the horizon. The future of treating cancer is now on the precipice of some amazing new information that I will be sharing with you in the next few weeks – STAY TUNED!

LISTEN TO GRACE GAWLER  VOICE AMERICA AUDIO
LISTEN TO GRACE GAWLER VOICE AMERICA AUDIO

This leads me to the real thrust of today’s show: That today in 2014 – in my experience in 40 years of working with cancer patients – that  it  is the strategies that a person employs in dealing with cancer that can make a difference to outcome and survival.

A How to Survive Cancer Manual is not given at the time of diagnosis!  How to survive and thrive – how to live well or die well – how to enhance life quality throughout adversity, how to adapt to changes around you and in your body, how to relate to those around you, how to really heal your life and grow though the experience of cancer are less popular  …. the real stuff of being a human with cancer is not to be found in juices and psuedo-science ….conventional medicine can help the body – but that is only one part of the story. Cancer patients who take charge of their life and make informed decisions clearly do well – even with advanced cancer.

Thanks for reading this blog and for listening to Voice America – Navigating the Cancer Maze. More on this topic in the next few days……Enjoy your day…..Grace

Resources mentioned in the show today:

How Surgeons can Help you Navigate the Colorectal Cancer Maze | Dr Francis Seow Choen with Grace Gawler

Dr Francis Seow Choen is himself a medical miracle. As a 7 year old he recovered from major surgery for a cancer in his small intestine after facing a horrendous 6 months of radiation treatment and chemotherapy back in 1964 when treatments were harsh. He survived! Dr. Seow-Choen graduated from the National University of Singapore in 1981 & obtained his higher surgical qualifications in 1987. He sub-specialised in colorectal surgery in 1989 where he worked with the world-class surgeons of St Marks’ Hospital in London. He is a remarkable CR surgeon.

Part 2 – How Surgeons can Help you Navigate the Colorectal Cancer Maze

Dr Francis Seow Choen MBBS (Spore), FRCS (Edin), FAMS

Dr Francis Seow Choen Fortis Surgical Hospital Singapore
Dr Francis Seow Choen Fortis Surgical Hospital Singapore

Dr Francis Seow Choen is himself a medical miracle. As a 7 year old he recovered from major surgery for a cancer in his small intestine after facing a horrendous 6 months of radiation treatment and chemotherapy back in 1964 when treatments were harsh. He survived! Interview CLICK HERE

Dr. Seow-Choen graduated from the National University of Singapore in 1981 & obtained his higher surgical qualifications in 1987. He sub-specialised in colorectal surgery in 1989 where he worked with the world-class surgeons of St Marks’ Hospital in London. He is a remarkable CR surgeon.

I have interviewed Dr Francis Seow Choen previously on my internet radio show Navigating the Cancer Maze at Voice America. This time however, we touch on more details about the surgical techniques available for anyone dealing with colorectal cancer today.

As well, speaking as CR surgeon and recovered patient; he had a powerful message to cancer patients. Listen to this short excerpt from his interview: Select the icon below right to hear Dr Seow Choen’s message.

A personal message to cancer patients from Dr Francis Seow Choen
A personal message to cancer patients from Dr Francis Seow Choen

I have tremendous respect for the art and science of surgery. My own introduction to surgery came when I was 15 years of age. I began working in a veterinary clinic after school, then during holidays and for while as permanent staff. I was fortunate that the owner took me on as an apprentice as he knew my passion was to become a veterinarian. So, not only did I learn “hands-on” labrador retriever at the vetsurgery at an early age – I also was involved in co-performing post postmortems on animals which has served as a treasured learning field for understanding anatomy, physiology and pathology – many older dogs and cats who succumbed to an advanced and previously undiagnosed cancer that became a postmortem exercise; allowed me to see a wide range of cancers in vivo.

On the other hand, I was also impressed in how quickly animals responded to surgery for cancer and that for a high percentage of our animal clients – of those  caught early in diagnosis; few had a recurrence. There were also cases where enormous tumour loads were surgically removed, and the dog lived a long life afterwards! It was here that I developed a tremendous respect for surgical skills and the associated healing potential and regenerative powers that along with our animal friends, we all possess. However, surgery has come a long way since those days when robotic surgery entered the arena a few years ago.

You will find today’s interview with Dr Seow Choen informative, especially regarding the techniques using the new DaVinci Robotic surgery technology. You can read more about this technique as well as listening to the interview with Dr Seow Choen at: http://www.voiceamerica.com/episode/80875/how-surgeons-can-help-you-navigate-the-colorectal-cancer-maze-part-2

Singapore Fortis surgical Hospital da-Vinci-Robotic-Surgery equipment
Singapore Fortis surgical Hospital da-Vinci-Robotic-Surgery equipment

 

Dr. Seow-Choen helped establish the first colorectal surgery department in Asia at Singapore General Hospital (SGH) and is considered a leader in the development in CR surgery and approaches to treatment.

In this interview with Dr Seow Choen he also comments on diet and nutrition for cancer patients from the viewpoint of an experienced CR surgeon.

You may be surprised what he says……

 In the last segment of today’s show, I provide an overview on treatments available for CR cancer in 2014. A not to be missed show!

DaVinci robotic surgery technology
DaVinci robotic surgery technology

Resources:

Contact: www.fortissurgicalhospital.com to learn more…..

Or visit Dr Seow Choen’s website:

http://www.colorectalcentre.com/eng/index.html 

Don’t miss reading the informative medical media articles  at……….

http://www.colorectalcentre.com/eng/media_articles.html

If you missed last weeks interview with Dr Seow Choen’s colleague Dr Lim Jit Fong –

CLICK HERE TO LISTEN

Remember all interviews on Navigating the Cancer Maze are free to air (on live streaming and available from the archives anytime) and can be downloaded for free on itunes.

The show is not copyright and is available to distribute in the interest of cancer education and public awareness.

The show is available globally and is sponsored by donations to the Grace Gawler Institute a registered NFP Health Promotion Charity with DGR status based in Australia with a global outreach.